Medpharm Biotech Company Review

Medpharm Biotech Company Review

MedPharm is a private company based in the Guildford United Kingdom. MedPharm came into existence in 1999. Activities of the company centre on biotech and pharmaceutical products and services. The company has been providing medicines to nonprofit aid groups, United Nations programs, and government agencies around the globe (The Chronicle of Philanthropy, 2011). The company works with World Health Organizations and the Bill and Melinda Gates Foundation (The Chronicle of Philanthropy, 2011). MedPharm company has a board of directors whose chief executive officer is Dr. Andrew G. Muddle while the chief scientific officer is Marc Brown.

Further, the company has a management team comprising of director of technical performance, director of clinical development, manager of pharmaceutical development and technical director of formulation development (MedPharm, 2013d). The number of the company employees fall below 50. MedPharm Biotech Company offers a broad range of services that entail formulation design, clinical trial manufacture, analytical services, and fast track to the clinic. For analytical services, specific activities include extractable and leachable. On formulation design, particular service provided include toxic testing, dermatological formulation, ophthalmic development and studying of skin metabolism.

What are the organisation’s activities in the field of science/ applied science, at a national and international level?

The company has GMP and GLP compliant laboratories located in Surrey Research Park. The company’s GLP facility consists of ISO compliant clean rooms. GMP and GLP facilities play a fundamental role in enhancing the company’s capability to provide a complete quality service for clinical trial supplies. Further, by employing the GLP and GMP facilities, MedPharm manufactures batches amounting up to 50 kilograms. Also, the company provides labelling and randomisation services courtesy of the two facilities.

Moreover, the GMP facility plays a significant role in validating the design process for aerosols semi-solutions, semi- solids (MedPharm, 2013c). Owing to GMP and GLP facilities, MedPharm is in a better position to offer a broad range of services not only nationally but even beyond the borders. The services provided by MedPharm in the field of science include analytical and microbiological testing, batch testing to provisional standards, sourcing of raw materials and manufacturing of batches to cGMP standards of topical dosage forms (MedPharm, 2013c). The topical dosage is significant in conducting ICH stability trials and clinical assessment for Phase I and II trials (MedPharm, 2013c).

At the national level, the company is tasked with the responsibility of manufacturing products at small-scale. The company serves over 150 healthcare centres across the world. Some of the services they provide to these health facilities include microscopy, analytical and performance test (The Chronicle of Philanthropy 2011). Also, the MedPharm offers API storage and microbiology. All these services are made possible by the company’s GLP compliant labs.

Scientific areas of particular interest. AquaRMed technology is designed to enhance retention of water in the epidermal part of the skin. The technology relieves the symptoms of dermatitis, Psoriasis and other conditions associated with poor skin hydration. Further, in vitro and ex vivo have shown that AquaRMed consists of anti-proinflammatory that ensures efficient drug permeation and penetration. Therefore, the technology plays a vital role in tackling skin inflammation. AquaRMed technology works in various areas including cosmetic industry in enhancing moisturisers used for dry skin (MedPharm, 2013a). Also, it can be applied in the pharmaceutical treatment of conditions associated with genetic filaggrin depletion. As a medical device, AquaRMed is vital in control of symptoms of Psoriasis, Cutaneous disorders, and dermatitis.

MedTherm Drug Delivery. MedTherm drug delivery is a novel active delivery system that works by using the components of thermophoresis together with excipients. The technology is designed to enhance delivery of compounds across the human skin. The system works by delivering the drug in the form of a heated patch, either liquid or semi- solid. The application site experiences a mild heating that enhances the transition of lipid phase, dilation of blood vessels and improves penetration. Therefore, the system facilitates improved drug delivery with a quick onset of action, direct application to the targeted site and works in local or systematic delivery. The system has proved successful in improving API drug delivery, for instance in Sildenafil: can 4-fold and Lidocaine, can 75-fold enhancements (MedPharm, 2013e).

MedSpray the Patch-in-a-Can. MedPharm Company has an aerosol-based system designed to deliver API as a Patch in a can. The novel spray on-patch works by producing a local patch that is densely saturated. The delivered local patch has several merits. One of the advantages is the aesthetic appeal that comes in since the saturated patch remains invisible once it is applied. Further, the spray delivery is convenient especially for users who do not desire to come into direct contact with the infected area when using the cream. Also, the aerosol delivery spray is designed to either deliver the API instantly or after a period hence it is flexible. The delivery technology is manufactured as a solution however it assembles into a micro-fine film during dose actuation. Med spray technology, therefore, improves delivery of therapeutic substances across the skin or buccal mucosa. Also, propellants used are environmentally friendly. Validation of medispray came through with a terbinafine formulation during clinical trials.

Who are the Main MedPharm Competitors?

MedPharm Biotech Company faces stiff competition from rival companies within the United Kingdom and even beyond. Some of the rival groups include West Pharma, Creabilis, Abzena, Allerdy Therapeutics, Ziarco among others. At the international level, MedPharm faces stiff competition from biotech firms such as Teva Pharmaceutical based in Israel, Biogen Idec and Regeneron Pharmaceuticals Inc. headquartered in the United States. However, despite the stiff competition, the company has improvised ways of gaining a competitive advantage over their rival companies. One of the ways in which the company strives to get a competitive edge is by investing in research and development, product differentiation and venturing into new markets.

Fast Track to the clinic

 MedPharm has a fast track formulation service. Therefore, the company welcomes clients who desire to take their projects further to human trials. By using specialist service, the company can track quickly topical formulations within the shortest period of four months excluding manufacturing period. By taking advantage of the company’s inherent risks, clients do achieve ultimate proof of concept for their products within the shortest time possible. The fast track service is considered a first-in-human clinical trial. The company also manufactures clinical trial materials within their GMP suites and submit them rapidly to their clinical trial sites. After achieving successful clinical trial, MedPharm works to enhance formulation, outstanding performance in each area of formulation characteristics before further clinical undertakings (MedPharm, 2013b).

 

 

Bibliography

MedPharm, 2013a, AquaRMed: Enhancing water retention in the epidermis.
Available from: <http://www.medpharm.co.uk/delivery-solutions/aquarmed/>.
[Accessed 6 April 2016].

MedPharm, 2013b, Fast track to the clinic.
Available from: <http://www.medpharm.co.uk/fast-track/>.
[Accessed 6 April 2016].

MedPharm, 2013c, GMP clinical manufacture & GLP facilities.
Available from: <http://www.medpharm.co.uk/about/facilities/>.
[Accessed 6 April 2016].

MedPharm, 2013d, MedPharm: Management.
Available at: <http://www.medpharm.co.uk/about/management/>.
[Accessed 6 April 2016].

MedPharm, 2013e, MedTherm® Drug Delivery. Available from: <http://www.medpharm.co.uk/delivery-solutions/medtherm-drug-delivery-2/>.
[Accessed 6 April 2016].

The Chronicle of Philanthropy, 2011, Controversy over drug values at aid groups: A look at a key player.
Available from: <https://philanthropy.com/article/Controversy-Over-Drug-Values/157511>.
[Accessed 6 April 2016].

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